DRAVP ID  DRAVPe01132

Peptide Name   gB122(636-650)

Sequence  GHRRYFTFGGGYVYF

Sequence Length  15

UniProt ID  P06437 

Source  Synthetic construct(derived from HSV-1 B glycoprotein (gB))

Target Organism  HSV

Assay  beta-galactosidase activity(Comprehensive antiviral assay,Virus inactivation assay,cell protection assay,entry assay,attachment assay)

Activity 

• [Ref.19104014]Herpes simplex virus type 1(HSV-1):comprehensive antiviral activity(EC50=15.0±2.2 µM);inhibition of virus entry in Vero cells(EC50=17.6±2.6 µM);inhibition of virus infection in Vero cells(EC50=71.5±17.4 µM);ability of inactive virus(EC50=118±11.6 µM);inhibition of virus attachment on Vero cells(EC50>200 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.19104014]Not cytotoxic for Vero cells up to 200 µM.

Binding Target  Not found

Mechanism  It is also possible that gB122 could either prematurely trigger or inhibit a conformational change in the gB-1 molecule required for entry,and may be acting by blocking a protein-protein interaction.

PDB ID  None

Predicted Structure Download  DRAVPe01132

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Multiple peptides homologous to herpes simplex virus type 1 glycoprotein B inhibit viral infection.

Pubmed ID   19104014

Reference   Antimicrob Agents Chemother. 2009 Mar;53(3):987-96.

Author   Akkarawongsa R, Pocaro NE, Case G, Kolb AW, Brandt CR.

DOI   10.1128/AAC.00793-08