DRAVP ID  DRAVPe01132

Peptide Name   gB122(636-650)

Sequence  GHRRYFTFGGGYVYF

Sequence Length  15

UniProt ID  P06437 

Taxon ID  None

Source  Synthetic construct(derived from HSV-1 B glycoprotein (gB))

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not available

Target Organism  HSV

Assay  beta-galactosidase activity(Comprehensive antiviral assay,Virus inactivation assay,cell protection assay,entry assay,attachment assay)

Activity 

• [Ref.19104014]Herpes simplex virus type 1(HSV-1):comprehensive antiviral activity(EC50=15.0±2.2 µM);inhibition of virus entry in Vero cells(EC50=17.6±2.6 µM);inhibition of virus infection in Vero cells(EC50=71.5±17.4 µM);ability of inactive virus(EC50=118±11.6 µM);inhibition of virus attachment on Vero cells(EC50>200 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.19104014]Not cytotoxic for Vero cells up to 200 µM.

Binding Target  Not found

Mechanism  It is also possible that gB122 could either prematurely trigger or inhibit a conformational change in the gB-1 molecule required for entry,and may be acting by blocking a protein-protein interaction.

PDB ID  None

Predicted Structure Download  DRAVPe01132

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Multiple peptides homologous to herpes simplex virus type 1 glycoprotein B inhibit viral infection.

Pubmed ID   19104014

Reference   Antimicrob Agents Chemother. 2009 Mar;53(3):987-96.

Author   Akkarawongsa R, Pocaro NE, Case G, Kolb AW, Brandt CR.

DOI   10.1128/AAC.00793-08