DRAVP ID  DRAVPe01133

Peptide Name   gB131(681-695)

Sequence  HEVVPLEVYTRHEIK

Sequence Length  15

UniProt ID  P06437 

Source  Synthetic construct(derived from HSV-1 B glycoprotein (gB))

Target Organism  HSV

Assay  beta-galactosidase activity(Comprehensive antiviral assay,Virus inactivation assay,cell protection assay,entry assay,attachment assay)

Activity 

• [Ref.19104014]Herpes simplex virus type 1(HSV-1):comprehensive antiviral activity(EC50=18.7±2.70 µM);inhibition of virus entry in Vero cells(EC50=12.2±6.56 µM);inhibition of virus infection in Vero cells(EC50>200 µM);ability of inactive virus(EC50>200 µM);inhibition of virus attachment on Vero cells(EC50>200 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.19104014]Not cytotoxic for Vero cells up to 200 µM.

Binding Target  Not found

Mechanism  The gB131 peptide could be interfering with a conformational change involving interactions between residues in this region or by blocking a binding interaction.

PDB ID  None

Predicted Structure Download  DRAVPe01133

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Multiple peptides homologous to herpes simplex virus type 1 glycoprotein B inhibit viral infection.

Pubmed ID   19104014

Reference   Antimicrob Agents Chemother. 2009 Mar;53(3):987-96.

Author   Akkarawongsa R, Pocaro NE, Case G, Kolb AW, Brandt CR.

DOI   10.1128/AAC.00793-08