DRAVP ID  DRAVPe01133

Peptide Name   gB131(681-695)

Sequence  HEVVPLEVYTRHEIK

Sequence Length  15

UniProt ID  P06437 

Taxon ID  None

Source  Synthetic construct(derived from HSV-1 B glycoprotein (gB))

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not available

Target Organism  HSV

Assay  beta-galactosidase activity(Comprehensive antiviral assay,Virus inactivation assay,cell protection assay,entry assay,attachment assay)

Activity 

• [Ref.19104014]Herpes simplex virus type 1(HSV-1):comprehensive antiviral activity(EC50=18.7±2.70 µM);inhibition of virus entry in Vero cells(EC50=12.2±6.56 µM);inhibition of virus infection in Vero cells(EC50>200 µM);ability of inactive virus(EC50>200 µM);inhibition of virus attachment on Vero cells(EC50>200 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.19104014]Not cytotoxic for Vero cells up to 200 µM.

Binding Target  Not found

Mechanism  The gB131 peptide could be interfering with a conformational change involving interactions between residues in this region or by blocking a binding interaction.

PDB ID  None

Predicted Structure Download  DRAVPe01133

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Multiple peptides homologous to herpes simplex virus type 1 glycoprotein B inhibit viral infection.

Pubmed ID   19104014

Reference   Antimicrob Agents Chemother. 2009 Mar;53(3):987-96.

Author   Akkarawongsa R, Pocaro NE, Case G, Kolb AW, Brandt CR.

DOI   10.1128/AAC.00793-08