General Information


DRAVP ID  DRAVPe01145

Peptide Name   gB122Δ10-15

Sequence  GHRRYFTFG

Sequence Length  9

UniProt ID  P06437 

Source  Synthetic construct(derived from HSV-1 B glycoprotein (gB))



Activity Information


Target Organism  HSV

Assay  beta-galactosidase activity(Comprehensive antiviral assay)

Activity 

  • [Ref.19104014]Herpes simplex virus type 1(HSV-1):comprehensive antiviral activity(EC50>100 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01145

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C53H73N17O12

Absent amino acids  ACDEIKLMNPQSVW

Common amino acids  FGR

Mass  1140.27

Pl  10.84

Basic residues  3

Acidic residues  0

Hydrophobic residues  2

Net charge  3

Boman Index  -2937

Hydrophobicity  -104.44

Aliphatic Index  0

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  1490

Absorbance 280nm  186.25

Polar residues  4



Literature Information


Literature 1

Title   Multiple peptides homologous to herpes simplex virus type 1 glycoprotein B inhibit viral infection.

Pubmed ID   19104014

Reference   Antimicrob Agents Chemother. 2009 Mar;53(3):987-96.

Author   Akkarawongsa R, Pocaro NE, Case G, Kolb AW, Brandt CR.

DOI   10.1128/AAC.00793-08