To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01147
Peptide Name FluA-PB1(3-25)
Sequence VNPTLLFLKVPAQNAISTTFPYT
Sequence Length 23
UniProt ID Q6DNS6
Source Synthetic construct(derived from INFV A polymerase (PB1))
Activity Information
Target Organism Influenza A
Assay ELISA
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target PA subunit
Mechanism Influenza virus replication and transcription is performed in the nucleus by the heterotrimeric viral polymerase complex consisting of the PB1, PB2, and PA subunits.The peptide could bind with PA subunit thus inhibit the virus replication.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01147
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C120H187N27O33
Absent amino acids CDEGHMRW
Common amino acids T
Mass 2535.97
Pl 8.56
Basic residues 1
Acidic residues 0
Hydrophobic residues 10
Net charge 1
Boman Index -85
Hydrophobicity 40.87
Aliphatic Index 101.74
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 67.73
Polar residues 8
Literature Information
Literature 1
Title Identification of a PA-binding peptide with inhibitory activity against influenza A and B virus replication.
Pubmed ID 19841738
Reference PLoS One. 2009 Oct 20;4(10):e7517.
Author Wunderlich K, Mayer D, Ranadheera C, Holler AS, Mänz B, Martin A, Chase G, Tegge W, Frank R, Kessler U, Schwemmle M.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.