General Information

General Information

DRAVP ID DRAVPe01176

Peptide Name 18-c01

Sequence GWWYKGRARPVSAVA

Sequence Length 15

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism H3N2,H1N1

Assay Plaque assay

Activity

[Ref.19558186]H1N1(A/PR/8/34):inhibition of virus infection in Madin-Darby canine kidney(MDCK) cells(IC50=3.2 μM);
H3N2(A/Aichi/2/68):inhibition of virus infection in Madin-Darby canine kidney(MDCK) cells(IC50>10 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity No cytotoxicity information found in the reference(s) presented

Binding Target sialylgalactose

Mechanism The peptide has affinity for glycoconjugates on the cell surface. And its binding to the cell resulted in the significant inhibition of influenza virus infections.

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01176

Linear/Cyclic Linear

N-terminal Modification Alkylated(C18)

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C80H118N24O18

Absent amino acids CDEFHILMNQT

Common amino acids A

Mass 1703.97

Pl 11

Basic residues 3

Acidic residues 0

Hydrophobic residues 7

Net charge 3

Boman Index -1888

Hydrophobicity -36

Aliphatic Index 58.67

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 12490

Absorbance 280nm 892.14

Polar residues 4

Literature Information

Literature 1

Title Inhibition of influenza virus infections by sialylgalactose-binding peptides selected from a phage library.

Pubmed ID 19558186

Reference J Med Chem. 2009 Jul 23;52(14):4247-56.

Author Matsubara T, Sumi M, Kubota H, Taki T, Okahata Y, Sato T.

DOI 10.1021/jm801570y