General Information

General Information

DRAVP ID DRAVPe01181

Peptide Name C18-p1b

Sequence DFRRLPGAFWQLRQP

Sequence Length 15

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism H3N2,H1N1

Assay Plaque assay

Activity

[Ref.19558186]H1N1(A/PR/8/34):inhibition of virus infection in Madin-Darby canine kidney(MDCK) cells(IC50=52 μM);
H3N2(A/Aichi/2/68):inhibition of virus infection in Madin-Darby canine kidney(MDCK) cells(IC50=19 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity No cytotoxicity information found in the reference(s) presented

Binding Target sialylgalactose

Mechanism The peptide has affinity for glycoconjugates on the cell surface. And its binding to the cell resulted in the significant inhibition of influenza virus infections.

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01181

Linear/Cyclic Linear

N-terminal Modification Alkylated(C18)

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C88H131N27O20

Absent amino acids CEHIKMNSTVY

Common amino acids R

Mass 1887.18

Pl 11.7

Basic residues 3

Acidic residues 1

Hydrophobic residues 6

Net charge 2

Boman Index -4368

Hydrophobicity -90

Aliphatic Index 58.67

Half Life

Mammalian:1.1 hour
Yeast:3 min
E.coli:>10 hour

Extinction Coefficient cystines 5500

Absorbance 280nm 392.86

Polar residues 1

Literature Information

Literature 1

Title Inhibition of influenza virus infections by sialylgalactose-binding peptides selected from a phage library.

Pubmed ID 19558186

Reference J Med Chem. 2009 Jul 23;52(14):4247-56.

Author Matsubara T, Sumi M, Kubota H, Taki T, Okahata Y, Sato T.

DOI 10.1021/jm801570y