DRAVP ID  DRAVPe01181

Peptide Name   C18-p1b

Sequence  DFRRLPGAFWQLRQP

Sequence Length  15

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  H3N2,H1N1

Assay  Plaque assay

Activity 

• [Ref.19558186]H1N1(A/PR/8/34):inhibition of virus infection in Madin-Darby canine kidney(MDCK) cells(IC50=52 μM);
• H3N2(A/Aichi/2/68):inhibition of virus infection in Madin-Darby canine kidney(MDCK) cells(IC50=19 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  sialylgalactose

Mechanism  The peptide has affinity for glycoconjugates on the cell surface. And its binding to the cell resulted in the significant inhibition of influenza virus infections.

PDB ID  None

Predicted Structure Download  DRAVPe01181

Linear/Cyclic  Linear

N-terminal Modification  Alkylated(C18)

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L

Literature 1

Title   Inhibition of influenza virus infections by sialylgalactose-binding peptides selected from a phage library. 

Pubmed ID   19558186

Reference   J Med Chem. 2009 Jul 23;52(14):4247-56.

Author   Matsubara T, Sumi M, Kubota H, Taki T, Okahata Y, Sato T.

DOI   10.1021/jm801570y