General Information


DRAVP ID  DRAVPe01202

Peptide Name   B9NP

Sequence  RRKKLLAVLLALLA

Sequence Length  14

UniProt ID  P08620 

Source  Synthetic construct(derived from FGF-4 signal sequence)

Other Link  DRAVPa1722



Activity Information


Target Organism  Influenza virus

Assay  Hemagglutinin assay

Activity 

  • [Ref.21220525]Influenza virus:inhibit hemagglutination of 64 HA units of virus of MDCK cells(EC50=3.1 ± 0.1 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Not found

Mechanism  The peptide inhibits influenza virus replication by preventing attachment to cells.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01202

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C74H140N22O15

Absent amino acids  CDEFGHIMNPQSTWY

Common amino acids  L

Mass  1578.06

Pl  12.02

Basic residues  4

Acidic residues  0

Hydrophobic residues  10

Net charge  4

Boman Index  -195

Hydrophobicity  111.43

Aliphatic Index  209.29

Half Life 

  •     Mammalian:1 hour
  •     Yeast:2 min
  •     E.coli:2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  0



Literature Information


Literature 1

Title   Identification of the minimal active sequence of an anti-influenza virus peptide. 

Pubmed ID   21220525

Reference    Antimicrob Agents Chemother. 2011 Apr;55(4):1810-3.

Author   Jones JC, Settles EW, Brandt CR, Schultz-Cherry S. 

DOI   10.1128/AAC.01428-10