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General Information
DRAVP ID DRAVPe01206
Peptide Name RJ3
Sequence KAAKKAAKAAKKAAKWAKKAA
Sequence Length 21
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism HSV
Assay Plaque reduction assay,ELISA
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Not found
Mechanism The peptide was able to inhibit the entry of HSV-1 into the host cell, probably by blocking heparan sulfate(HS) at the cell surface.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01206
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C98H175N31O22
Absent amino acids CDEFGHILMNPQRSTVY
Common amino acids A
Mass 2139.66
Pl 10.9
Basic residues 9
Acidic residues 0
Hydrophobic residues 12
Net charge 9
Boman Index -2771
Hydrophobicity -77.14
Aliphatic Index 52.38
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 275
Polar residues 0
Literature Information
Literature 1
Title A wide range of medium-sized, highly cationic, alpha-helical peptides show antiviral activity against herpes simplex virus.
Pubmed ID 15498607
Reference Antiviral Res. 2004 Nov;64(2):119-26.
Author Jenssen H, Andersen JH, Mantzilas D, Gutteberg TJ.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.