DRAVP ID  DRAVPe01207

Peptide Name   RJ5

Sequence  AKKAAKKAKKAAKKAKKAAKK

Sequence Length  21

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  HSV

Assay  Plaque reduction assay,ELISA

Activity 

• [Ref.15498607]herpes simplex virus 1(HSV-1):inhibition of HSV-1 infection in MRC-5 cells(IC50=41.0 μM);
• herpes simplex virus 2(HSV-2):inhibition of HSV-2 infection in MRC-5 cells(IC50=14.3 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.15498607]human fibroblasts(MRC-5 cells):CC50>468 μM.

Binding Target  Not found

Mechanism  The peptide was able to inhibit the entry of HSV-1 into the host cell, probably by blocking heparan sulfate(HS) at the cell surface.

PDB ID  None

Predicted Structure Download  DRAVPe01207

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   A wide range of medium-sized, highly cationic, alpha-helical peptides show antiviral activity against herpes simplex virus.

Pubmed ID   15498607

Reference   Antiviral Res. 2004 Nov;64(2):119-26.

Author   Jenssen H, Andersen JH, Mantzilas D, Gutteberg TJ. 

DOI   10.1016/j.antiviral.2004.08.003