General Information

General Information

DRAVP ID DRAVPe01212

Peptide Name RJ10

Sequence ARRAKRRARRAKRRARRKKRR

Sequence Length 21

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism HSV

Assay Plaque reduction assay,ELISA

Activity

[Ref.15498607]herpes simplex virus 1(HSV-1):inhibition of HSV-1 infection in MRC-5 cells(IC50=24.6 μM);
herpes simplex virus 2(HSV-2):inhibition of HSV-2 infection in MRC-5 cells(IC50=54.7 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.15498607]human fibroblasts(MRC-5 cells):CC50>422 μM.

Binding Target Not found

Mechanism The peptide was able to inhibit the entry of HSV-1 into the host cell, probably by blocking heparan sulfate(HS) at the cell surface.

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01212

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C111H219N61O22

Absent amino acids CDEFGHILMNPQSTVWY

Common amino acids R

Mass 2760.36

Pl 13.04

Basic residues 16

Acidic residues 0

Hydrophobic residues 5

Net charge 16

Boman Index -19219

Hydrophobicity -288.57

Aliphatic Index 23.81

Half Life

Mammalian:4.4 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 0

Literature Information

Literature 1

Title A wide range of medium-sized, highly cationic, alpha-helical peptides show antiviral activity against herpes simplex virus.

Pubmed ID 15498607

Reference Antiviral Res. 2004 Nov;64(2):119-26.

Author Jenssen H, Andersen JH, Mantzilas D, Gutteberg TJ.

DOI 10.1016/j.antiviral.2004.08.003