General Information


DRAVP ID  DRAVPe01214

Peptide Name   C12a(FIV ectodomain 768-779)

Sequence  QKWEDWVRWIGN

Sequence Length  12

UniProt ID  P16090 

Source  Synthetic construct(derived from the Membrane-Proximal Ectodomain of Feline Immunodeficiency Virus)



Activity Information


Target Organism  FIV

Assay  enzyme-linked immunosorbent assay(ELISA)

Activity 

  • [Ref.12610147]FIV-M2(Feline immunodeficiency virus M2):inhibition of virus replication in MBM cells(IC50=0.25 µg/ml);
  • FIV-Pet(Feline immunodeficiency virus Pet):inhibition of virus replication in MBM cells(IC50=0.18 µg/ml).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01214

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C76H105N21O19

Absent amino acids  ACFHLMPSTY

Common amino acids  W

Mass  1616.8

Pl  6.07

Basic residues  2

Acidic residues  2

Hydrophobic residues  5

Net charge  0

Boman Index  -3129

Hydrophobicity  -140

Aliphatic Index  56.67

Half Life 

  •     Mammalian:0.8 hour
  •     Yeast:10 min
  •     E.coli:>10 hour

Extinction Coefficient cystines  16500

Absorbance 280nm  1500

Polar residues  2



Literature Information


Literature 1

Title   Antiviral activity and conformational features of an octapeptide derived from the membrane-proximal ectodomain of the feline immunodeficiency virus transmembrane glycoprotein.

Pubmed ID   12610147

Reference   J Virol. 2003 Mar;77(6):3724-33.

Author   Giannecchini S, Di Fenza A, D'Ursi AM, Matteucci D, Rovero P, Bendinelli M.

DOI   10.1128/jvi.77.6.3724-3733.2003