General Information

General Information

DRAVP ID DRAVPe01218

Peptide Name C6a(FIV ectodomain 772-777)

Sequence DWVRWI

Sequence Length 6

UniProt ID P16090

Source Synthetic construct(derived from the Membrane-Proximal Ectodomain of Feline Immunodeficiency Virus)

Activity Information

Target Organism FIV

Assay enzyme-linked immunosorbent assay(ELISA)

Activity

[Ref.12610147]FIV-M2(Feline immunodeficiency virus M2):inhibition of virus replication in MBM cells(IC50=0.15 µg/ml);
FIV-Pet(Feline immunodeficiency virus Pet):inhibition of virus replication in MBM cells(IC50=0.07 µg/ml).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity No cytotoxicity information found in the reference(s) presented

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01218

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C43H59N11O9

Absent amino acids ACEFGHKLMNPQSTY

Common amino acids W

Mass 874.01

Pl 5.84

Basic residues 1

Acidic residues 1

Hydrophobic residues 4

Net charge 0

Boman Index -1002

Hydrophobicity -18.33

Aliphatic Index 113.33

Half Life

Mammalian:1.1 hour
Yeast:3 min
E.coli:>10 hour

Extinction Coefficient cystines 11000

Absorbance 280nm 2200

Polar residues 0

Literature Information

Literature 1

Title Antiviral activity and conformational features of an octapeptide derived from the membrane-proximal ectodomain of the feline immunodeficiency virus transmembrane glycoprotein.

Pubmed ID 12610147

Reference J Virol. 2003 Mar;77(6):3724-33.

Author Giannecchini S, Di Fenza A, D'Ursi AM, Matteucci D, Rovero P, Bendinelli M.

DOI 10.1128/jvi.77.6.3724-3733.2003