General Information

General Information

DRAVP ID DRAVPe01222

Peptide Name C4b(FIV ectodomain 774-777)

Sequence VRWI

Sequence Length 4

UniProt ID P16090

Taxon ID None

Source Synthetic construct(derived from the Membrane-Proximal Ectodomain of Feline Immunodeficiency Virus)

Validation Experimentally Validated

Origin Information

Gene Name/ID Not Available

GenBank Not Available

Amino Acid position Not Available

Domain Accession ID Not Available

Nucleotide sequence ID Not Available

Molecular Type Not Available

Chromosomal Position Not available

Activity Information

Target Organism FIV

Assay enzyme-linked immunosorbent assay(ELISA)

Activity

[Ref.12610147]FIV-M2(Feline immunodeficiency virus M2):inhibition of virus replication in MBM cells(IC50=7.80 µg/ml);
FIV-Pet(Feline immunodeficiency virus Pet):inhibition of virus replication in MBM cells(IC50=4.06 µg/ml).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity No cytotoxicity information found in the reference(s) presented

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01222

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C28H44N8O5

Absent amino acids ACDEFGHKLMNPQSTY

Common amino acids IRVW

Mass 572.71

Pl 9.72

Basic residues 1

Acidic residues 0

Hydrophobic residues 3

Net charge 1

Boman Index -363

Hydrophobicity 82.5

Aliphatic Index 170

Half Life

Mammalian:100 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 5500

Absorbance 280nm 1833.33

Polar residues 0

Literature Information

Literature 1

Title Antiviral activity and conformational features of an octapeptide derived from the membrane-proximal ectodomain of the feline immunodeficiency virus transmembrane glycoprotein.

Pubmed ID 12610147

Reference J Virol. 2003 Mar;77(6):3724-33.

Author Giannecchini S, Di Fenza A, D'Ursi AM, Matteucci D, Rovero P, Bendinelli M.

DOI 10.1128/jvi.77.6.3724-3733.2003