General Information
DRAVP ID DRAVPe01288
Peptide Name DV3(419-447)
Sequence AWDFGSVGGVLNSLGKMVHQIFGSAYTAL
Sequence Length 29
UniProt ID Q99D35
Source Synthetic construct(derived from DENV3 E protein stem)
Activity Information
Target Organism DENV
Assay Plaque assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Not found
Mechanism The peptide shows antiviral activity by inhibiting virus entry.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01288
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C139H209N35O39S
Absent amino acids CEPR
Common amino acids G
Mass 3026.46
Pl 6.79
Basic residues 2
Acidic residues 1
Hydrophobic residues 13
Net charge 1
Boman Index 855
Hydrophobicity 56.9
Aliphatic Index 94.14
Half Life
Extinction Coefficient cystines 6990
Absorbance 280nm 249.64
Polar residues 11
Literature Information
Literature 1
Title Peptide inhibitors of flavivirus entry derived from the E protein stem.
Pubmed ID 20881042
Reference J Virol. 2010 Dec;84(24):12549-54.
Author Schmidt AG, Yang PL, Harrison SC.