DRAVP ID  DRAVPe01289

Peptide Name   DV4(419-447)

Sequence  AWDFGSVGGLFTSLGKAVHQVFGSVYTTM

Sequence Length  29

UniProt ID  P27909 

Taxon ID  None

Source  Synthetic construct(derived from DENV4 E protein stem)

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not available

Target Organism  DENV

Assay  Plaque assay

Activity 

• [Ref.20881042]Dengue 1 virus(DENV1):inhibition of infection in BHK-21 cells(IC90=5 μM);
• Dengue 2 virus(DENV2):inhibition of infection in BHK-21 cells(IC90=6 μM);
• Dengue 3 virus(DENV3):inhibition of infection in BHK-21 cells(IC90>6 μM);
• Dengue 4 virus(DENV4):inhibition of infection in BHK-21 cells(IC90=6 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Not found

Mechanism  The peptide shows antiviral activity by inhibiting virus entry.

PDB ID  None

Predicted Structure Download  DRAVPe01289

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Peptide inhibitors of flavivirus entry derived from the E protein stem.

Pubmed ID   20881042

Reference   J Virol. 2010 Dec;84(24):12549-54.

Author   Schmidt AG, Yang PL, Harrison SC.

DOI   10.1128/JVI.01440-10