General Information

General Information

DRAVP ID DRAVPe01289

Peptide Name DV4(419-447)

Sequence AWDFGSVGGLFTSLGKAVHQVFGSVYTTM

Sequence Length 29

UniProt ID P27909

Source Synthetic construct(derived from DENV4 E protein stem)

Activity Information

Target Organism DENV

Assay Plaque assay

Activity

[Ref.20881042]Dengue 1 virus(DENV1):inhibition of infection in BHK-21 cells(IC90=5 μM);
Dengue 2 virus(DENV2):inhibition of infection in BHK-21 cells(IC90=6 μM);
Dengue 3 virus(DENV3):inhibition of infection in BHK-21 cells(IC90>6 μM);
Dengue 4 virus(DENV4):inhibition of infection in BHK-21 cells(IC90=6 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity No cytotoxicity information found in the reference(s) presented

Binding Target Not found

Mechanism The peptide shows antiviral activity by inhibiting virus entry.

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01289

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C142H208N34O40S

Absent amino acids CEINPR

Common amino acids G

Mass 3063.48

Pl 6.79

Basic residues 2

Acidic residues 1

Hydrophobic residues 12

Net charge 1

Boman Index 542

Hydrophobicity 53.45

Aliphatic Index 73.79

Half Life

Mammalian:4.4 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 6990

Absorbance 280nm 249.64

Polar residues 12

Literature Information

Literature 1

Title Peptide inhibitors of flavivirus entry derived from the E protein stem.

Pubmed ID 20881042

Reference J Virol. 2010 Dec;84(24):12549-54.

Author Schmidt AG, Yang PL, Harrison SC.

DOI 10.1128/JVI.01440-10