To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01369
Peptide Name Ac[Tyr7(OMe)]H2-(7-15)
Sequence XAGAVVNDL
Sequence Length 9
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism HSV
Assay Ribonucleotide reductase assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target ribonucleotide reductase
Mechanism The peptide inhibits the activity of ribonucleotide rductase.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Acetylation
C-terminal Modification Free
Other Modification The 'X' at position 1 is methoxy Tyrosine.
Stereochemistry L
Physicochemical Information
Formula C32H53N9O11
Absent amino acids CEFHIKMPQRSTWY
Common amino acids AV
Mass 869.17
Pl 3.8
Basic residues 0
Acidic residues 1
Hydrophobic residues 5
Net charge -1
Boman Index 220
Hydrophobicity 93.33
Aliphatic Index 130
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Literature Information
Literature 1
Title Structure-activity studies on synthetic peptides inhibiting herpes simplex virus ribonucleotide reductase.
Pubmed ID 3040743
Reference J Biol Chem. 1987 Sep 15;262(26):12413-6.
Author Gaudreau P, Michaud J, Cohen EA, Langelier Y, Brazeau P.
DOI Not available
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.