To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01373
Peptide Name [β-Ala8]H2-(7-15)
Sequence YXGAVVNDL
Sequence Length 9
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism HSV
Assay Ribonucleotide reductase assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target ribonucleotide reductase
Mechanism The peptide inhibits the activity of ribonucleotide rductase.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification The 'X' at position 2 is 3-aminoproprionic acid.
Stereochemistry L
Physicochemical Information
Formula C38H57N9O12
Absent amino acids CEFHIKMPQRSTW
Common amino acids V
Mass 961.27
Pl 3.8
Basic residues 0
Acidic residues 1
Hydrophobic residues 4
Net charge -1
Boman Index 25
Hydrophobicity 58.89
Aliphatic Index 118.89
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 186.25
Polar residues 3
Literature Information
Literature 1
Title Structure-activity studies on synthetic peptides inhibiting herpes simplex virus ribonucleotide reductase.
Pubmed ID 3040743
Reference J Biol Chem. 1987 Sep 15;262(26):12413-6.
Author Gaudreau P, Michaud J, Cohen EA, Langelier Y, Brazeau P.
DOI Not available
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.