General Information


DRAVP ID  DRAVPe01383

Peptide Name   D2B15

Sequence  GAKKGAKKGKKGAKKGAKGAGAKGAGAFKKKK

Sequence Length  32

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  FIV

Assay  reverse transcriptase (RT) assay

Activity 

  • [Ref.12208971]Feline immunodeficiency virus(FIV-Petaluma):inhibition of reverse transcriptase activity in CrFK cells(IC50=4.07 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.12208971]CrFK cell:TC50=6.19 μM.

Binding Target  Not found

Mechanism  The peptide may facilitate interference with viral assembly or release and reduce the number of infectious progeny virions.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01383

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C135H246N46O33

Absent amino acids  CDEHILMNPQRSTVWY

Common amino acids  K

Mass  3041.73

Pl  11.11

Basic residues  14

Acidic residues  0

Hydrophobic residues  9

Net charge  14

Boman Index  -5178

Hydrophobicity  -128.13

Aliphatic Index  25

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  9



Literature Information


Literature 1

Title   Inhibitory activity of synthetic peptide antibiotics on feline immunodeficiency virus infectivity in vitro. 

Pubmed ID   12208971

Reference   J Virol. 2002 Oct;76(19):9952-61.

Author   Ma J, Kennedy-Stoskopf S, Jaynes JM, Thurmond LM, Tompkins WA.

DOI   10.1128/jvi.76.19.9952-9961.2002