General Information


DRAVP ID  DRAVPe01385

Peptide Name   D2A3

Sequence  KKKKFVKKVAKKVKKVAKKVAKVAVAV

Sequence Length  27

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  FIV

Assay  reverse transcriptase (RT) assay

Activity 

  • [Ref.12208971]Feline immunodeficiency virus(FIV-Petaluma):inhibition of reverse transcriptase activity in CrFK cells(IC50=3.00 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.12208971]CrFK cell:TC50=3.24 μM.

Binding Target  Not found

Mechanism  The peptide may facilitate interference with viral assembly or release and reduce the number of infectious progeny virions.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01385

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C142H264N40O28

Absent amino acids  CDEGHILMNPQRSTWY

Common amino acids  K

Mass  2979.91

Pl  11.08

Basic residues  13

Acidic residues  0

Hydrophobic residues  14

Net charge  13

Boman Index  -2780

Hydrophobicity  -19.63

Aliphatic Index  104.44

Half Life 

  •     Mammalian:1.3 hour
  •     Yeast:3 min
  •     E.coli:2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  0



Literature Information


Literature 1

Title   Inhibitory activity of synthetic peptide antibiotics on feline immunodeficiency virus infectivity in vitro. 

Pubmed ID   12208971

Reference   J Virol. 2002 Oct;76(19):9952-61.

Author   Ma J, Kennedy-Stoskopf S, Jaynes JM, Thurmond LM, Tompkins WA.

DOI   10.1128/jvi.76.19.9952-9961.2002