To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01399
Peptide Name UL54(1221-1241)
Sequence LPRRLHLEPAFLPYSVKAHEC
Sequence Length 21
UniProt ID P08546
Source Synthetic construct(derived from human cytomegalovirus(HCMV) UL54 protein)
Activity Information
Target Organism HCMV
Assay ELISA
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target DNA polymerase
Mechanism Peptide derived from C-terminus of UL54 can block the physical interaction between UL54 and UL44,thus inhibits the activity of DNA polymerase.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01399
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C114H178N32O28S
Absent amino acids DGIMNQTW
Common amino acids L
Mass 2476.93
Pl 8.22
Basic residues 5
Acidic residues 2
Hydrophobic residues 8
Net charge 3
Boman Index -3027
Hydrophobicity -23.33
Aliphatic Index 97.62
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 74.5
Polar residues 3
Literature Information
Literature 1
Title Inhibition of human cytomegalovirus DNA polymerase by C-terminal peptides from the UL54 subunit.
Pubmed ID 12857903
Reference J Virol. 2003 Aug;77(15):8336-44.
Author Loregian A, Rigatti R, Murphy M, Schievano E, Palu G, Marsden HS.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.