General Information


DRAVP ID  DRAVPe01418

Peptide Name   SARSWW-III(1028-1049)

Sequence  GYHLMSFPQAAPHGVVFLHVTW

Sequence Length  22

UniProt ID  P11224 

Source  Synthetic construct(derived from SARS-CoV spike protein)



Activity Information


Target Organism  SARS-CoV

Assay  Plaque formation assay

Activity 

  • [Ref.16616792]SARS-CoV:inhibition of plaque information on Vero E6 cells(90% inhibition at ~30 μM,IC50=2 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.16616792]No cytotoxicity against Vero E6 cells up to 30 μM.

Binding Target  membrane

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01418

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C120H168N30O27S

Absent amino acids  CDEIKNR

Common amino acids  HV

Mass  2494.9

Pl  7.02

Basic residues  3

Acidic residues  0

Hydrophobic residues  10

Net charge  3

Boman Index  1247

Hydrophobicity  47.73

Aliphatic Index  84.09

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  6990

Absorbance 280nm  332.86

Polar residues  5



Literature Information


Literature 1

Title   Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike protein

Pubmed ID   16616792

Reference   Virus Res. 2006 Sep;120(1-2):146-55.

Author   Sainz B Jr, Mossel EC, Gallaher WR, Wimley WC, Peters CJ, Wilson RB, Garry RF. 

DOI   10.1016/j.virusres.2006.03.001