General Information


DRAVP ID  DRAVPe01419

Peptide Name   SARSWW-IV(1075-1093)

Sequence  GVFVFNGTSWFITQRNFFS

Sequence Length  19

UniProt ID  P11224 

Source  Synthetic construct(derived from SARS-CoV spike protein)



Activity Information


Target Organism  SARS-CoV

Assay  Plaque formation assay

Activity 

  • [Ref.16616792]SARS-CoV:inhibition of plaque information on Vero E6 cells(83% inhibition at ~30 μM,IC50=2 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.16616792]No cytotoxicity against Vero E6 cells up to 30 μM.

Binding Target  membrane

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01419

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C109H148N26O27

Absent amino acids  ACDEHKLMPY

Common amino acids  F

Mass  2254.53

Pl  9.75

Basic residues  1

Acidic residues  0

Hydrophobic residues  9

Net charge  1

Boman Index  -1357

Hydrophobicity  37.89

Aliphatic Index  51.05

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  5500

Absorbance 280nm  305.56

Polar residues  8



Literature Information


Literature 1

Title   Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike protein

Pubmed ID   16616792

Reference   Virus Res. 2006 Sep;120(1-2):146-55.

Author   Sainz B Jr, Mossel EC, Gallaher WR, Wimley WC, Peters CJ, Wilson RB, Garry RF. 

DOI   10.1016/j.virusres.2006.03.001