General Information

General Information

DRAVP ID DRAVPe01421

Peptide Name MHVWW-IV(1144-1162)

Sequence GYFVQDDGEWKFTGSSYYY

Sequence Length 19

UniProt ID P11224

Taxon ID None

Source Synthetic construct(derived from MHV spike protein)

Validation Experimentally Validated

Origin Information

Gene Name/ID Not Available

GenBank Not Available

Amino Acid position Not Available

Domain Accession ID Not Available

Nucleotide sequence ID Not Available

Molecular Type Not Available

Chromosomal Position Not Available

Activity Information

Target Organism SARS-CoV

Assay Plaque formation assay

Activity

[Ref.16616792]SARS-CoV:inhibition of plaque information on Vero E6 cells(IC50=4 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.16616792]No cytotoxicity against Vero E6 cells up to 30 μM.

Binding Target membrane

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01421

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C110H138N22O34

Absent amino acids ACHILMNPR

Common amino acids Y

Mass 2312.43

Pl 4.03

Basic residues 1

Acidic residues 3

Hydrophobic residues 4

Net charge -2

Boman Index -3012

Hydrophobicity -93.16

Aliphatic Index 15.26

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 11460

Absorbance 280nm 636.67

Polar residues 10

Literature Information

Literature 1

Title Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike protein

Pubmed ID 16616792

Reference Virus Res. 2006 Sep;120(1-2):146-55.

Author Sainz B Jr, Mossel EC, Gallaher WR, Wimley WC, Peters CJ, Wilson RB, Garry RF.

DOI 10.1016/j.virusres.2006.03.001