General Information

General Information

DRAVP ID DRAVPe01423

Peptide Name gH493-512(derived from HSV-1 H glycoprotein)

Sequence AAHLIDALYAEFLGGRVLTT

Sequence Length 20

UniProt ID Q9DHD5

Source Synthetic construct(derived from HSV-1 H glycoprotein (gH))

Activity Information

Target Organism HSV

Assay Plaque assay

Activity

[Ref.18572274]Herpes simplex virus type 1(HSV-1):inhibition of viral-entry in Vero cells(60% inhibition at 250μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.18572274]No cytotoxicity against Vero cells up to 500 μM.

Binding Target mambrane

Mechanism The peptide inhibits virus entry and thus protects cells from infection.

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01423

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C98H155N25O28

Absent amino acids CKMNPQSW

Common amino acids AL

Mass 2131.46

Pl 5.32

Basic residues 2

Acidic residues 2

Hydrophobic residues 11

Net charge 0

Boman Index 35

Hydrophobicity 78.5

Aliphatic Index 132

Half Life

Mammalian:4.4 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 1490

Absorbance 280nm 78.42

Polar residues 5

Literature Information

Literature 1

Title Peptides containing membrane-interacting motifs inhibit herpes simplex virus type 1 infectivity.

Pubmed ID 18572274

Reference Peptides. 2008 Sep;29(9):1461-71.

Author Galdiero S, Falanga A, Vitiello M, D'Isanto M, Cantisani M, Kampanaraki A, Benedetti E, Browne H, Galdiero M.

DOI 10.1016/j.peptides.2008.04.022