General Information


DRAVP ID  DRAVPe01426

Peptide Name   Pcr-Δ8

Sequence  LNITNSHVSILQERPPLENRVL

Sequence Length  22

UniProt ID  P14075 

Source  Synthetic construct(derived from HTLV-1 envelope glycoprotein (gp21))



Activity Information


Target Organism  HTLV

Assay  Luciferase assay

Activity 

  • [Ref.19114713]:Human T cell leukemia virus type 1(HTLV-1):inhibition of mambrane fusion in 293T cells(IC50=5.8 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  membrane

Mechanism  The peptide is an effective inhibitor of HTLV-1 envelope-catalyzed membrane fusion and thus inhibits virus entry.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01426

Linear/Cyclic  Linear

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C111H188N34O34

Absent amino acids  ACDFGKMWY

Common amino acids  L

Mass  2542.92

Pl  6.76

Basic residues  3

Acidic residues  2

Hydrophobic residues  8

Net charge  1

Boman Index  -4535

Hydrophobicity  -27.73

Aliphatic Index  132.73

Half Life 

  •     Mammalian:5.5 hour
  •     Yeast:3 min
  •     E.coli:2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  6



Literature Information


Literature 1

Title   Basic residues are critical to the activity of peptide inhibitors of human T cell leukemia virus type 1 entry.

Pubmed ID   19114713

Reference   J Biol Chem. 2009 Mar 6;284(10):6575-84. 

Author   Lamb D, Mirsaliotis A, Kelly SM, Brighty DW.

DOI   10.1074/jbc.M806725200