To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01426
Peptide Name Pcr-Δ8
Sequence LNITNSHVSILQERPPLENRVL
Sequence Length 22
UniProt ID P14075
Taxon ID None
Source Synthetic construct(derived from HTLV-1 envelope glycoprotein (gp21))
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not available
Activity Information
Target Organism HTLV
Assay Luciferase assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target membrane
Mechanism The peptide is an effective inhibitor of HTLV-1 envelope-catalyzed membrane fusion and thus inhibits virus entry.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01426
Linear/Cyclic Linear
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C111H188N34O34
Absent amino acids ACDFGKMWY
Common amino acids L
Mass 2542.92
Pl 6.76
Basic residues 3
Acidic residues 2
Hydrophobic residues 8
Net charge 1
Boman Index -4535
Hydrophobicity -27.73
Aliphatic Index 132.73
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 6
Literature Information
Literature 1
Title Basic residues are critical to the activity of peptide inhibitors of human T cell leukemia virus type 1 entry.
Pubmed ID 19114713
Reference J Biol Chem. 2009 Mar 6;284(10):6575-84.
Author Lamb D, Mirsaliotis A, Kelly SM, Brighty DW.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.