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General Information
DRAVP ID DRAVPe01429
Peptide Name Pcr-R422A
Sequence CFLNITNSHVSILQEAPPLENAV
Sequence Length 23
UniProt ID P14075
Source Synthetic construct(derived from HTLV-1 envelope glycoprotein (gp21))
Activity Information
Target Organism HTLV
Assay Luciferase assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target membrane
Mechanism The peptide is an effective inhibitor of HTLV-1 envelope-catalyzed membrane fusion and thus inhibits virus entry.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01429
Linear/Cyclic Linear
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C111H177N29O35S
Absent amino acids DGKMRWY
Common amino acids LN
Mass 2509.86
Pl 4.51
Basic residues 1
Acidic residues 2
Hydrophobic residues 10
Net charge -1
Boman Index -1255
Hydrophobicity 34.78
Aliphatic Index 118.7
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 7
Literature Information
Literature 1
Title Basic residues are critical to the activity of peptide inhibitors of human T cell leukemia virus type 1 entry.
Pubmed ID 19114713
Reference J Biol Chem. 2009 Mar 6;284(10):6575-84.
Author Lamb D, Mirsaliotis A, Kelly SM, Brighty DW.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.