General Information


DRAVP ID  DRAVPe01446

Peptide Name   G162-177

Sequence  DFHFEVFNFVPBSIBG

Sequence Length  16

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  RSV

Assay  NMR

Activity 

  • [Ref.11487583]Respiratory syncytial virus(RSV):inhibition of the cytopathic effect of RSV in HEp-2 cells(IC50=60 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01446

Linear/Cyclic  Linear

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  The 'B' at position 12,15 are S-acetamidomethyl cysteine.

Stereochemistry  L



Physicochemical Information


Formula  C81H103N17O19

Absent amino acids  ACKLMQRTWY

Common amino acids  F

Mass  1884.15

Pl  4.35

Basic residues  1

Acidic residues  2

Hydrophobic residues  7

Net charge  -1

Boman Index  -437

Hydrophobicity  47.5

Aliphatic Index  60.63

Half Life 

  •     Mammalian:1.1 hour
  •     Yeast:3 min
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  3



Literature Information


Literature 1

Title   Antiviral activity and structural characteristics of the nonglycosylated central subdomain of human respiratory syncytial virus attachment (G) glycoprotein.

Pubmed ID   11487583

Reference   J Biol Chem. 2001 Oct 19;276(42):38988-94.

Author   Gorman JJ, McKimm-Breschkin JL, Norton RS, Barnham KJ. 

DOI   10.1074/jbc.M106288200