General Information


DRAVP ID  DRAVPe01464

Peptide Name   P8

Sequence  CDVIALLCHLNT

Sequence Length  12

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  WNV

Assay  RT-QPCR

Activity 

  • [Ref.17151121]west nile virus(WNV):inhibition of virus infection in Vero cells(P10 significantly inhibited WNV infectivity).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  E proteins

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01464

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C56H95N15O17S2

Absent amino acids  EFGKMPQRSWY

Common amino acids  L

Mass  1314.58

Pl  5.08

Basic residues  1

Acidic residues  1

Hydrophobic residues  6

Net charge  0

Boman Index  550

Hydrophobicity  133.33

Aliphatic Index  162.5

Half Life 

  •     Mammalian:1.2 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  125

Absorbance 280nm  11.36

Polar residues  4



Literature Information


Literature 1

Title   Antiviral peptides targeting the west nile virus envelope protein.

Pubmed ID   17151121

Reference   J Virol. 2007 Feb;81(4):2047-55. 

Author   Bai F, Town T, Pradhan D, Cox J, Ashish, Ledizet M, Anderson JF, Flavell RA, Krueger JK, Koski RA, Fikrig E.

DOI   10.1128/JVI.01840-06