General Information

General Information

DRAVP ID DRAVPe01465

Peptide Name P9

Sequence CDVIALLACHLNT

Sequence Length 13

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism WNV

Assay RT-QPCR

Activity

[Ref.17151121]west nile virus(WNV):inhibition of virus infection in Vero cells(96.3±2.8% inhibition at 100 μM,IC50=2.60 ± 0.01 μM);inhibition of virus entry in Vero cells(65.2±14.5% inhibition at 100 μM);inhibition of virus attachment to Vero cells(96.3±2.7% inhibition at 1mM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.17151121]No cytotoxicity against Vero cells up to 500μM.

Binding Target E proteins

Mechanism P9 blocked cirus attachment

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01465

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C59H100N16O18S2

Absent amino acids EFGKMPQRSWY

Common amino acids L

Mass 1385.66

Pl 5.08

Basic residues 1

Acidic residues 1

Hydrophobic residues 7

Net charge 0

Boman Index 731

Hydrophobicity 136.92

Aliphatic Index 157.69

Half Life

Mammalian:1.2 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 125

Absorbance 280nm 10.42

Polar residues 4

Literature Information

Literature 1

Title Antiviral peptides targeting the west nile virus envelope protein.

Pubmed ID 17151121

Reference J Virol. 2007 Feb;81(4):2047-55.

Author Bai F, Town T, Pradhan D, Cox J, Ashish, Ledizet M, Anderson JF, Flavell RA, Krueger JK, Koski RA, Fikrig E.

DOI 10.1128/JVI.01840-06