General Information

General Information

DRAVP ID DRAVPe01465

Peptide Name P9

Sequence CDVIALLACHLNT

Sequence Length 13

UniProt ID No entry found

Taxon ID None

Source Synthetic construct

Validation Experimentally Validated

Origin Information

Gene Name/ID Not Available

GenBank Not Available

Amino Acid position Not Available

Domain Accession ID Not Available

Nucleotide sequence ID Not Available

Molecular Type Not Available

Chromosomal Position Not available

Activity Information

Target Organism WNV

Assay RT-QPCR

Activity

[Ref.17151121]west nile virus(WNV):inhibition of virus infection in Vero cells(96.3±2.8% inhibition at 100 μM,IC50=2.60 ± 0.01 μM);inhibition of virus entry in Vero cells(65.2±14.5% inhibition at 100 μM);inhibition of virus attachment to Vero cells(96.3±2.7% inhibition at 1mM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.17151121]No cytotoxicity against Vero cells up to 500μM.

Binding Target E proteins

Mechanism P9 blocked cirus attachment

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01465

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C59H100N16O18S2

Absent amino acids EFGKMPQRSWY

Common amino acids L

Mass 1385.66

Pl 5.08

Basic residues 1

Acidic residues 1

Hydrophobic residues 7

Net charge 0

Boman Index 731

Hydrophobicity 136.92

Aliphatic Index 157.69

Half Life

Mammalian:1.2 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 125

Absorbance 280nm 10.42

Polar residues 4

Literature Information

Literature 1

Title Antiviral peptides targeting the west nile virus envelope protein.

Pubmed ID 17151121

Reference J Virol. 2007 Feb;81(4):2047-55.

Author Bai F, Town T, Pradhan D, Cox J, Ashish, Ledizet M, Anderson JF, Flavell RA, Krueger JK, Koski RA, Fikrig E.

DOI 10.1128/JVI.01840-06