General Information


DRAVP ID  DRAVPe01468

Peptide Name   A4

Sequence  SSCNMGWDTPACCVWFPYWV

Sequence Length  20

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  HCMV

Assay  GFP assay

Activity 

  • [Ref.19740994]human cytomegalovirus(HCMV):inhibition of virus replication in HeLa cells(70% inhibition).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  pUL84(nonconventional nuclear localization signal of the essential viral replication factor)

Mechanism  The peptide specifically bind to UL84 protein and utilized to inhibit HCMV replication.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01468

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C108H142N24O28S4

Absent amino acids  EHIKLQR

Common amino acids  CW

Mass  2352.7

Pl  3.8

Basic residues  0

Acidic residues  1

Hydrophobic residues  7

Net charge  -1

Boman Index  212

Hydrophobicity  27.5

Aliphatic Index  34

Half Life 

  •     Mammalian:1.9 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  18115

Absorbance 280nm  953.42

Polar residues  9



Literature Information


Literature 1

Title   Inhibition of human cytomegalovirus replication via peptide aptamers directed against the nonconventional nuclear localization signal of the essential viral replication factor pUL84.

Pubmed ID   19740994

Reference   J Virol. 2009 Nov;83(22):11902-13. 

Author   Kaiser N, Lischka P, Wagenknecht N, Stamminger T.

DOI   10.1128/JVI.01378-09