To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01468
Peptide Name A4
Sequence SSCNMGWDTPACCVWFPYWV
Sequence Length 20
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism HCMV
Assay GFP assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target pUL84(nonconventional nuclear localization signal of the essential viral replication factor)
Mechanism The peptide specifically bind to UL84 protein and utilized to inhibit HCMV replication.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01468
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C108H142N24O28S4
Absent amino acids EHIKLQR
Common amino acids CW
Mass 2352.7
Pl 3.8
Basic residues 0
Acidic residues 1
Hydrophobic residues 7
Net charge -1
Boman Index 212
Hydrophobicity 27.5
Aliphatic Index 34
Half Life
Extinction Coefficient cystines 18115
Absorbance 280nm 953.42
Polar residues 9
Literature Information
Literature 1
Title Inhibition of human cytomegalovirus replication via peptide aptamers directed against the nonconventional nuclear localization signal of the essential viral replication factor pUL84.
Pubmed ID 19740994
Reference J Virol. 2009 Nov;83(22):11902-13.
Author Kaiser N, Lischka P, Wagenknecht N, Stamminger T.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.