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General Information
DRAVP ID DRAVPe01469
Peptide Name A8
Sequence MAVGLVLCDWWLGEYLLEA
Sequence Length 19
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism HCMV
Assay GFP assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target pUL84(nonconventional nuclear localization signal of the essential viral replication factor)
Mechanism The peptide specifically bind to UL84 protein and utilized to inhibit HCMV replication.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01469
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C103H153N21O27S2
Absent amino acids FHIKNPQRST
Common amino acids L
Mass 2181.59
Pl 3.57
Basic residues 0
Acidic residues 3
Hydrophobic residues 11
Net charge -3
Boman Index 2399
Hydrophobicity 110.53
Aliphatic Index 143.68
Half Life
Extinction Coefficient cystines 12490
Absorbance 280nm 693.89
Polar residues 4
Literature Information
Literature 1
Title Inhibition of human cytomegalovirus replication via peptide aptamers directed against the nonconventional nuclear localization signal of the essential viral replication factor pUL84.
Pubmed ID 19740994
Reference J Virol. 2009 Nov;83(22):11902-13.
Author Kaiser N, Lischka P, Wagenknecht N, Stamminger T.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.