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General Information
DRAVP ID DRAVPe01476
Peptide Name Peptide 75(710-725)[Δ1-5]
Sequence KWEYVLLLFLL
Sequence Length 11
UniProt ID P26663
Source Synthetic construct(derived from HCV envelope protein)
Activity Information
Target Organism HCV
Assay Luciferase assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target envelope protein
Mechanism The peptide inhibits a post-binding step in HCV entry.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01476
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C75H113N13O15
Absent amino acids ACDGHIMNPQRST
Common amino acids L
Mass 1436.8
Pl 6
Basic residues 1
Acidic residues 1
Hydrophobic residues 8
Net charge 0
Boman Index 2145
Hydrophobicity 149.09
Aliphatic Index 203.64
Half Life
Extinction Coefficient cystines 6990
Absorbance 280nm 699
Polar residues 1
Literature Information
Literature 1
Title A peptide derived from hepatitis C virus E2 envelope protein inhibits a post-binding step in HCV entry.
Pubmed ID 20156485
Reference Antiviral Res. 2010 May;86(2):172-9.
Author Liu R, Tewari M, Kong R, Zhang R, Ingravallo P, Ralston R.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.