General Information

General Information

DRAVP ID DRAVPe01483

Peptide Name Peptide 75(710-725)

Sequence VSFAIKWEYVLLLFLL

Sequence Length 16

UniProt ID P26663

Taxon ID None

Source Synthetic construct(derived from HCV envelope protein)

Validation Experimentally Validated

Origin Information

Gene Name/ID Not Available

GenBank Not Available

Amino Acid position Not Available

Domain Accession ID Not Available

Nucleotide sequence ID Not Available

Molecular Type Not Available

Chromosomal Position Not Available

Activity Information

Target Organism HCV

Assay Luciferase assay

Activity

[Ref.20156485]hepatitis C virus(HCVpp):inhibition of virus infection in Huh-7 human hepatoma cells(EC50=0.3 ± 0.4 μM,EC90=14 ± 12 μM);inhibition of virus infection in primary human hepatocytes(EC50=0.3μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.20156485]No cytotoxicity against Huh-7 cells.

Binding Target envelope protein

Mechanism The peptide inhibits a post-binding step in HCV entry.

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01483

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C101H152N18O21

Absent amino acids CDGHMNPQRT

Common amino acids L

Mass 1954.43

Pl 5.97

Basic residues 1

Acidic residues 1

Hydrophobic residues 12

Net charge 0

Boman Index 3180

Hydrophobicity 180.63

Aliphatic Index 188.75

Half Life

Mammalian:100 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 6990

Absorbance 280nm 466

Polar residues 2

Literature Information

Literature 1

Title A peptide derived from hepatitis C virus E2 envelope protein inhibits a post-binding step in HCV entry.

Pubmed ID 20156485

Reference Antiviral Res. 2010 May;86(2):172-9.

Author Liu R, Tewari M, Kong R, Zhang R, Ingravallo P, Ralston R.

DOI 10.1016/j.antiviral.2010.02.316