General Information

General Information

DRAVP ID DRAVPe01483

Peptide Name Peptide 75(710-725)

Sequence VSFAIKWEYVLLLFLL

Sequence Length 16

UniProt ID P26663

Source Synthetic construct(derived from HCV envelope protein)

Activity Information

Target Organism HCV

Assay Luciferase assay

Activity

[Ref.20156485]hepatitis C virus(HCVpp):inhibition of virus infection in Huh-7 human hepatoma cells(EC50=0.3 ± 0.4 μM,EC90=14 ± 12 μM);inhibition of virus infection in primary human hepatocytes(EC50=0.3μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.20156485]No cytotoxicity against Huh-7 cells.

Binding Target envelope protein

Mechanism The peptide inhibits a post-binding step in HCV entry.

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01483

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C101H152N18O21

Absent amino acids CDGHMNPQRT

Common amino acids L

Mass 1954.43

Pl 5.97

Basic residues 1

Acidic residues 1

Hydrophobic residues 12

Net charge 0

Boman Index 3180

Hydrophobicity 180.63

Aliphatic Index 188.75

Half Life

Mammalian:100 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 6990

Absorbance 280nm 466

Polar residues 2

Literature Information

Literature 1

Title A peptide derived from hepatitis C virus E2 envelope protein inhibits a post-binding step in HCV entry.

Pubmed ID 20156485

Reference Antiviral Res. 2010 May;86(2):172-9.

Author Liu R, Tewari M, Kong R, Zhang R, Ingravallo P, Ralston R.

DOI 10.1016/j.antiviral.2010.02.316