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General Information
DRAVP ID DRAVPe01484
Peptide Name DN57opt
Sequence RWMVWRHWFHRLRLPYNPGKNKQNQQWP
Sequence Length 28
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism DENV
Assay Focus reduction assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target E glycoprotein
Mechanism The peptide blocks virus:cell binding, interfere with a step during viral entry, alter the surface structure of dengue viral particles, and that they interact directly with dengue virus envelope protein.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01484
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C176H252N56O36S
Absent amino acids ACDEIST
Common amino acids RW
Mass 3760.35
Pl 12.01
Basic residues 8
Acidic residues 0
Hydrophobic residues 8
Net charge 8
Boman Index -8731
Hydrophobicity -167.14
Aliphatic Index 38.21
Half Life
Extinction Coefficient cystines 23490
Absorbance 280nm 870
Polar residues 5
Literature Information
Literature 1
Title Structural optimization and de novo design of dengue virus entry inhibitory peptides.
Pubmed ID 20582308
Reference PLoS Negl Trop Dis. 2010 Jun 22;4(6):e721.
Author Costin JM, Jenwitheesuk E, Lok SM, Hunsperger E, Conrads KA, Fontaine KA, Rees CR, Rossmann MG, Isern S, Samudrala R, Michael SF.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.