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General Information
DRAVP ID DRAVPe01485
Peptide Name DN81opt
Sequence RQMRAWGQDYQHGGMGYSC
Sequence Length 19
UniProt ID No entry found
Taxon ID None
Source Synthetic construct
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism DENV
Assay Focus reduction assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target E glycoprotein
Mechanism The peptide blocks virus:cell binding, interfere with a step during viral entry, alter the surface structure of dengue viral particles, and that they interact directly with dengue virus envelope protein.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01485
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C93H135N31O28S3
Absent amino acids EFIKLNPTV
Common amino acids G
Mass 2231.47
Pl 8.21
Basic residues 3
Acidic residues 1
Hydrophobic residues 2
Net charge 2
Boman Index -4964
Hydrophobicity -126.32
Aliphatic Index 5.26
Half Life
Extinction Coefficient cystines 8480
Absorbance 280nm 471.11
Polar residues 8
Literature Information
Literature 1
Title Structural optimization and de novo design of dengue virus entry inhibitory peptides.
Pubmed ID 20582308
Reference PLoS Negl Trop Dis. 2010 Jun 22;4(6):e721.
Author Costin JM, Jenwitheesuk E, Lok SM, Hunsperger E, Conrads KA, Fontaine KA, Rees CR, Rossmann MG, Isern S, Samudrala R, Michael SF.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.