DRAVP ID  DRAVPe01486

Peptide Name   1OAN1

Sequence  FWFTLIKTQAKQPARYRRFC

Sequence Length  20

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  DENV

Assay  Focus reduction assay

Activity 

• [Ref.20582308]dengue 2 virus(DENV-2):inhibition of virus infection in LLC-MK2 cells(IC50=7±4 μM,99% inhibition at 50 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.20582308]the peptide showed no toxic to LLC-MK2 cells at 50 µM.

Binding Target  E glycoprotein

Mechanism  The peptide blocks virus:cell binding, interfere with a step during viral entry, alter the surface structure of dengue viral particles, and that they interact directly with dengue virus envelope protein.

PDB ID  None

Predicted Structure Download  DRAVPe01486

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Structural optimization and de novo design of dengue virus entry inhibitory peptides.

Pubmed ID   20582308

Reference   PLoS Negl Trop Dis. 2010 Jun 22;4(6):e721. 

Author   Costin JM, Jenwitheesuk E, Lok SM, Hunsperger E, Conrads KA, Fontaine KA, Rees CR, Rossmann MG, Isern S, Samudrala R, Michael SF.

DOI   10.1371/journal.pntd.0000721