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General Information
DRAVP ID DRAVPe01486
Peptide Name 1OAN1
Sequence FWFTLIKTQAKQPARYRRFC
Sequence Length 20
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism DENV
Assay Focus reduction assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target E glycoprotein
Mechanism The peptide blocks virus:cell binding, interfere with a step during viral entry, alter the surface structure of dengue viral particles, and that they interact directly with dengue virus envelope protein.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01486
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C121H182N34O26S
Absent amino acids DEGHMNSV
Common amino acids FR
Mass 2561.05
Pl 11.01
Basic residues 5
Acidic residues 0
Hydrophobic residues 8
Net charge 5
Boman Index -4621
Hydrophobicity -53.5
Aliphatic Index 49
Half Life
Extinction Coefficient cystines 6990
Absorbance 280nm 367.89
Polar residues 4
Literature Information
Literature 1
Title Structural optimization and de novo design of dengue virus entry inhibitory peptides.
Pubmed ID 20582308
Reference PLoS Negl Trop Dis. 2010 Jun 22;4(6):e721.
Author Costin JM, Jenwitheesuk E, Lok SM, Hunsperger E, Conrads KA, Fontaine KA, Rees CR, Rossmann MG, Isern S, Samudrala R, Michael SF.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.