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General Information
DRAVP ID DRAVPe01498
Peptide Name GBVA12(6-23)
Sequence VRLGRYLLRRLKTPFTRL
Sequence Length 18
UniProt ID Q69422
Source Synthetic construct(derived from GBVA non-structutal protein 5A)
Activity Information
Target Organism HCV
Assay qRT-PCR assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Not found
Mechanism The peptide inhibits virus entry.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01498
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C104H180N34O22
Absent amino acids ACDEHIMNQSW
Common amino acids LR
Mass 2258.79
Pl 12.18
Basic residues 6
Acidic residues 0
Hydrophobic residues 7
Net charge 6
Boman Index -5287
Hydrophobicity -28.33
Aliphatic Index 124.44
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 87.65
Polar residues 4
Literature Information
Literature 1
Title Screening and rational design of hepatitis C virus entry inhibitory peptides derived from GB virus A NS5A.
Pubmed ID 23175359
Reference J Virol. 2013 Feb;87(3):1649-57.
Author Liu X, Huang Y, Cheng M, Pan L, Si Y, Li G, Niu Y, Zhao L, Zhao J, Li X, Chen Y, Yang W.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.