DRAVP ID  DRAVPe01507

Peptide Name   GBVA10-9(P16L)

Sequence  CWVRLGRYLLRRLKTLFT

Sequence Length  18

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct(derived from GBVA non-structutal protein 5A)

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  HCV

Assay  qRT-PCR assay

Activity 

• [Ref.23175359]hepatitis C virus(Jc1-Luc HCVcc):inhibition of virus entry in Huh7.5.1 cells(IC50=0.16 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.23175359]HepG2 cell:LC50=90 μM(4h of treatment);
• HeLa cell:LC50=40 μM(4h of treatment);
• Huh7.5.1 cell:LC50=90 μM(4h of treatment);LC50=50 μM(24h of treatment).

Binding Target  Not found

Mechanism  GBVA10-9 can inhibit virus entry at a postattachment step.

PDB ID  None

Predicted Structure Download  DRAVPe01507

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Screening and rational design of hepatitis C virus entry inhibitory peptides derived from GB virus A NS5A.

Pubmed ID   23175359

Reference   J Virol. 2013 Feb;87(3):1649-57.

Author   Liu X, Huang Y, Cheng M, Pan L, Si Y, Li G, Niu Y, Zhao L, Zhao J, Li X, Chen Y, Yang W.

DOI   10.1128/JVI.02201-12