General Information

General Information

DRAVP ID DRAVPe01528

Peptide Name Temporin-Sha[K3]

Sequence FLKGIVGMLGKLF

Sequence Length 13

UniProt ID No entry found

Source Synthetic construct(derived from Temporin-SHa)

Activity Information

Target Organism HSV

Assay

Activity

[Ref.30669255]HSV-1:inhibition of HSV-1 replication in human keratinocytes(48% inhibition at 2.5 µM,57% inhibition at 5 µM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.30669255]Significant cytotoxicity was observed on Keratinocyte at the concentration of 10 μM with a cell viability of 74%.

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01528

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C70H115N15O14S

Absent amino acids ACDEHNPQRSTWY

Common amino acids GL

Mass 1422.84

Pl 10

Basic residues 2

Acidic residues 0

Hydrophobic residues 7

Net charge 2

Boman Index 2375

Hydrophobicity 143.08

Aliphatic Index 142.31

Half Life

Mammalian:1.1 hour
Yeast:3 min
E.coli:2 min

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 3

Literature Information

Literature 1

Title Comparison of Anti-Viral Activity of Frog Skin Anti-Microbial Peptides Temporin-Sha and [K³]SHa to LL-37 and Temporin-Tb against Herpes Simplex Virus Type 1.

Pubmed ID 30669255

Reference Viruses. 2019 Jan 18;11(1):77.

Author Roy M, Lebeau L, Chessa C, Damour A, Ladram A, Oury B, Boutolleau D, Bodet C, Lévêque N.

DOI 10.3390/v11010077