General Information


DRAVP ID  DRAVPe01531

Peptide Name   LL-23

Sequence  LLGDLLRKSKEKIGKEFKRIVQR

Sequence Length  23

UniProt ID  No entry found

Source  Synthetic construct(derived from human cathelicidin LL-37)



Activity Information


Target Organism  HIV

Assay 

Activity 

  • [Ref.18591279]HIV-1IIIB:inhibition the cytopathic effect of HIV in CEM-SS cells(EC50>35.4 μM).(EC50:50% effective concentration for inhibition of virus replication)

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.18591279]CEM-SS cells:TC50>35.4 μM.(TC50:the concentration that reduced cell viability by 50%)

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01531

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C124H220N38O32

Absent amino acids  ACHMNPTWY

Common amino acids  K

Mass  2755.35

Pl  10.55

Basic residues  8

Acidic residues  3

Hydrophobic residues  8

Net charge  5

Boman Index  -6537

Hydrophobicity  -75.65

Aliphatic Index  114.35

Half Life 

  •     Mammalian:5.5 hour
  •     Yeast:3 min
  •     E.coli:2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  3



Literature Information


Literature 1

Title   Anti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins.

Pubmed ID   18591279

Reference   Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. 

Author   Wang G, Watson KM, Buckheit RW Jr. 

DOI   10.1128/AAC.00452-08