General Information

General Information

DRAVP ID DRAVPe01533

Peptide Name SK-21

Sequence SKEKIGKEFKRIVQRIKDFLR

Sequence Length 21

UniProt ID No entry found

Source Synthetic construct(derived from human cathelicidin LL-37)

Activity Information

Target Organism HIV

Assay

Activity

[Ref.18591279]HIV-1IIIB:inhibition the cytopathic effect of HIV in CEM-SS cells(EC50=10.8 μM).(EC50:50% effective concentration for inhibition of virus replication)

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.18591279]CEM-SS cells:TC50=22.5 μM.(TC50:the concentration that reduced cell viability by 50%)

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01533

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C119H204N36O30

Absent amino acids ACHMNPTWY

Common amino acids K

Mass 2619.15

Pl 10.55

Basic residues 8

Acidic residues 3

Hydrophobic residues 7

Net charge 5

Boman Index -7317

Hydrophobicity -100.48

Aliphatic Index 88.1

Half Life

Mammalian:1.9 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 2

Literature Information

Literature 1

Title Anti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins.

Pubmed ID 18591279

Reference Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40.

Author Wang G, Watson KM, Buckheit RW Jr.

DOI 10.1128/AAC.00452-08