DRAVP ID  DRAVPe01537

Peptide Name   HA-pep25

Sequence  SKVNGQSGRMEFFWTILK

Sequence Length  18

UniProt ID  No entry found

Source  Synthetic construct(derived from influenza viral HA)

Target Organism  Influenza A virus

Assay  Infection assay

Activity 

• [Ref.27623031]Influenza A Virus(A/PuertoRico/8/1934):inhibition of virus entry into Madin Darby canine kidney (MDCK) cells(IC50=34.0 ± 11.5μM);
• AInfluenza A Virus(/Vietnam/1203/2004):inhibition of virus entry into Madin Darby canine kidney (MDCK) cells(IC50=12.0 ± 2.1μM);
• influenza A virus(A/Goose/Qinghai/59/2005):inhibition of virus entry into Madin Darby canine kidney (MDCK) cells(IC50=34.8 ± 1.5μM);
• influenza A virus(A/Duck/Anhui/SC702/2013):inhibition of virus entry into Madin Darby canine kidney (MDCK) cells(IC50=51.0 ± 0.6μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  HA receptor binding domain (RBD)

Mechanism  Block the HA–cell interactions by binding to the influenza host cell receptor sialyllactose and thus inhibit the viral entry.

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Influenza Viral Hemagglutinin Peptide Inhibits Influenza Viral Entry by Shielding the Host Receptor

Pubmed ID   27623031

Reference   ACS Infect Dis. 2016 Mar 11;2(3):187-93

Author   Chen Q, Guo Y

DOI   10.1021/acsinfecdis.5b00139