General Information


DRAVP ID  DRAVPe01538

Peptide Name   GF-17d1

Sequence  GFKRIVQRiKDFLRNLV

Sequence Length  17

UniProt ID  No entry found

Source  Synthetic construct(derived from human cathelicidin LL-37)



Activity Information


Target Organism  HIV

Assay 

Activity 

  • [Ref.18591279]HIV-1IIIB:inhibition the cytopathic effect of HIV in CEM-SS cells(EC50>47.5 μM).(EC50:50% effective concentration for inhibition of virus replication)

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.18591279]CEM-SS cells:TC50=22.7 μM.(TC50:the concentration that reduced cell viability by 50%)

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  Mixed(D-Ile9)



Physicochemical Information


Formula  C91H151N29O20

Absent amino acids  ACEHMPSTWY

Common amino acids  R

Mass  2102.56

Pl  11.72

Basic residues  5

Acidic residues  1

Hydrophobic residues  7

Net charge  4

Boman Index  -4702

Hydrophobicity  -35.88

Aliphatic Index  102.94

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  2



Literature Information


Literature 1

Title   Anti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins.

Pubmed ID   18591279

Reference   Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. 

Author   Wang G, Watson KM, Buckheit RW Jr. 

DOI   10.1128/AAC.00452-08