General Information

General Information

DRAVP ID DRAVPe01542

Peptide Name GI-20W17

Sequence GIKEWKRIVQRIKDFLRNLV

Sequence Length 20

UniProt ID No entry found

Taxon ID None

Source Synthetic construct(derived from human cathelicidin LL-37)

Validation Experimentally Validated

Origin Information

Gene Name/ID Not Available

GenBank Not Available

Amino Acid position Not Available

Domain Accession ID Not Available

Nucleotide sequence ID Not Available

Molecular Type Not Available

Chromosomal Position Not available

Activity Information

Target Organism HIV

Assay

Activity

[Ref.18591279]HIV-1IIIB:inhibition the cytopathic effect of HIV in CEM-SS cells(EC50=7.4 μM).(EC50:50% effective concentration for inhibition of virus replication)

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.18591279]CEM-SS cells:TC50=23.6 μM.(TC50:the concentration that reduced cell viability by 50%)

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01542

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C116H195N35O27

Absent amino acids ACHMPSTY

Common amino acids IKR

Mass 2512.04

Pl 11

Basic residues 6

Acidic residues 2

Hydrophobic residues 9

Net charge 4

Boman Index -5019

Hydrophobicity -41

Aliphatic Index 126.5

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 5500

Absorbance 280nm 289.47

Polar residues 2

Literature Information

Literature 1

Title Anti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins.

Pubmed ID 18591279

Reference Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40.

Author Wang G, Watson KM, Buckheit RW Jr.

DOI 10.1128/AAC.00452-08