General Information

General Information

DRAVP ID DRAVPe01550

Peptide Name BMAP-28 (BMAP28, bovine myeloid antimicrobial peptide 28; natural AMPs; cathelicidin-5, cattle, ruminant, mammals, animals; BBMm;ZZP; UCLL1; Derivatives: mBMAP-28

Sequence GGLRSLGRKILRAWKKYGPIIVPIIRIG

Sequence Length 28

UniProt ID P54229

Source Cow Bos taurus

Activity Information

Target Organism HSV,PRCV

Assay

Activity

[Ref.15019203]Herpes simplex virus type 1(HSV-1):72% protection from HSV-1 and 72% inhibited of viral replication in Vero cells at 5 μM;
porcine respiratory corona virus(PRCV):did not prove active against PRCV at 0.5–50 μM in Swine Testicular (ST) cells.

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.15019203]17% cytotoxic against Vero76 cells at 5 μM;95% cytotoxic against Vero76 cells at 50 μM.

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID 2NDC

Predicted Structure Download DRAVPe01550

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C147H252N44O31

Absent amino acids CDEFHMNQT

Common amino acids I

Mass 3131.89

Pl 12.02

Basic residues 7

Acidic residues 0

Hydrophobic residues 12

Net charge 7

Boman Index -2271

Hydrophobicity 23.21

Aliphatic Index 139.29

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 6990

Absorbance 280nm 258.89

Polar residues 7

Literature Information

Literature 1

Title In vitro and in vivo antimicrobial activity of two alpha-helical cathelicidin peptides and of their synthetic analogs.

Pubmed ID 15019203

Reference Peptides. 2003 Nov;24(11):1723-31.

Author Benincasa M, Skerlavaj B, Gennaro R, Pellegrini A, Zanetti M.

DOI 10.1016/j.peptides.2003.07.025