DRAVP ID  DRAVPe01550

Peptide Name   BMAP-28 (BMAP28, bovine myeloid antimicrobial peptide 28; natural AMPs; cathelicidin-5, cattle, ruminant, mammals, animals; BBMm;ZZP; UCLL1; Derivatives: mBMAP-28

Sequence  GGLRSLGRKILRAWKKYGPIIVPIIRIG

Sequence Length  28

UniProt ID  P54229 

Taxon ID  None

Source  Cow Bos taurus

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  HSV,PRCV

Assay 

Activity 

• [Ref.15019203]Herpes simplex virus type 1(HSV-1):72% protection from HSV-1 and 72% inhibited of viral replication in Vero cells at 5 μM;
• porcine respiratory corona virus(PRCV):did not prove active against PRCV at 0.5–50 μM in Swine Testicular (ST) cells.

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.15019203]17% cytotoxic against Vero76 cells at 5 μM;95% cytotoxic against Vero76 cells at 50 μM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry

PDB ID  2NDC 

Predicted Structure Download  DRAVPe01550

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L

Literature 1

Title   In vitro and in vivo antimicrobial activity of two alpha-helical cathelicidin peptides and of their synthetic analogs.

Pubmed ID   15019203

Reference   Peptides. 2003 Nov;24(11):1723-31.

Author   Benincasa M, Skerlavaj B, Gennaro R, Pellegrini A, Zanetti M. 

DOI   10.1016/j.peptides.2003.07.025