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General Information
DRAVP ID DRAVPe01551
Peptide Name Temporin G
Sequence FFPVIGRILNGIL
Sequence Length 13
UniProt ID P79875
Source European common frog, Rana temporaria
Activity Information
Target Organism influenza virus,Sendai virus
Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Not found
Mechanism Temporin G block the conformational rearrangements of HA2 subunit, which are essential for the viral envelope fusion with intracellular endocytic vesicles, thereby neutralizing the virus entry into the host cell.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01551
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C72H115N17O15
Absent amino acids ACDEHKMQSTWY
Common amino acids I
Mass 1458.81
Pl 9.75
Basic residues 1
Acidic residues 0
Hydrophobic residues 8
Net charge 1
Boman Index 1492
Hydrophobicity 157.69
Aliphatic Index 172.31
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Literature Information
Literature 1
Title Temporin G, an amphibian antimicrobial peptide against influenza and parainfluenza respiratory viruses: Insights into biological activity and mechanism of action.
Pubmed ID 33538061
Reference FASEB J. 2021 Feb;35(2):e21358.
Author De Angelis M, Casciaro B, Genovese A, Brancaccio D, Marcocci ME, Novellino E, Carotenuto A, Palamara AT, Mangoni ML, Nencioni L.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.