General Information


DRAVP ID  DRAVPe01552

Peptide Name   EC-hepcidin1

Sequence  MKTFSVAVAVAIVLAFICTQESSALPVTGVEELVELVSSDDPVADHQELPVELGERLFNIRKKRASPKCTPYCYPTRDGVFCGVRCDF

Sequence Length  88

UniProt ID  No entry found

Source  Epinephelus coioides



Activity Information


Target Organism  SGIV

Assay 

Activity 

  • [Ref.21145974]Singapore grouper iridovirus (SGIV):strongly inhibit the replication of SGIV.(EC-hepcidin1 is more active than EC-hepcidin2)

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01552

Linear/Cyclic  Cyclic

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  There are two pairs of disulfide bonds.

Stereochemistry  L



Physicochemical Information


Formula  C429H682N112O129S6

Absent amino acids  W

Common amino acids  V

Mass  9665.17

Pl  4.99

Basic residues  10

Acidic residues  12

Hydrophobic residues  34

Net charge  -2

Boman Index  -10622

Hydrophobicity  17.73

Aliphatic Index  91.82

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  3230

Absorbance 280nm  37.13

Polar residues  23



Literature Information


Literature 1

Title   Molecular cloning and characterization of two novel hepcidins from orange-spotted grouper, Epinephelus coioides. 

Pubmed ID   21145974

Reference   Fish Shellfish Immunol. 2011 Feb;30(2):559-68. 

Author   Zhou JG, Wei JG, Xu D, Cui HC, Yan Y, Ou-Yang ZL, Huang XH, Huang YH, Qin QW.

DOI   10.1016/j.fsi.2010.11.021