General Information

General Information

DRAVP ID DRAVPe01554

Peptide Name Dermaseptin-1

Sequence ALWKTMLKKLGTMALHAGKAALGAAADTISQGTQ

Sequence Length 34

UniProt ID P24302 P80277

Source Phyllomedusa sauvagei (Sauvage's leaf frog)

Activity Information

Target Organism CCV,FV3

Assay

Activity

[Ref.15193922]Channel Catfish virus(CCV): inhibition of CCV infection in catfish ovary(CCO) cells(reduce viral infectivity by 50% at 3 μM);
Frog Virus 3(FV3): inhibition of FV3 infection in fathead minnow(FHM) cells(reduce viral infectivity by 50% at 12 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.11601906]No cytotoxicity against catfish ovary(CCO) cells at 0.1-11.4 μM.

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01554

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C152H257N43O44S2

Absent amino acids CEFNPRVY

Common amino acids A

Mass 3455.09

Pl 10

Basic residues 5

Acidic residues 1

Hydrophobic residues 15

Net charge 4

Boman Index -555

Hydrophobicity 18.53

Aliphatic Index 92.35

Half Life

Mammalian:4.4 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 5500

Absorbance 280nm 166.67

Polar residues 9

Literature Information

Literature 1

Title Inactivation of viruses infecting ectothermic animals by amphibian and piscine antimicrobial peptides.

Pubmed ID 15193922

Reference Virology. 2004 Jun 1;323(2):268-75.

Author Chinchar VG, Bryan L, Silphadaung U, Noga E, Wade D, Rollins-Smith L.

DOI 10.1016/j.virol.2004.02.029