DRAVP ID  DRAVPe01554

Peptide Name   Dermaseptin-1

Sequence  ALWKTMLKKLGTMALHAGKAALGAAADTISQGTQ

Sequence Length  34

UniProt ID  P24302  P80277 

Taxon ID  None

Source  Phyllomedusa sauvagei (Sauvage's leaf frog)

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  CCV,FV3

Assay 

Activity 

• [Ref.15193922]Channel Catfish virus(CCV): inhibition of CCV infection in catfish ovary(CCO) cells(reduce viral infectivity by 50% at 3 μM);
• Frog Virus 3(FV3): inhibition of FV3 infection in fathead minnow(FHM) cells(reduce viral infectivity by 50% at 12 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.11601906]No cytotoxicity against catfish ovary(CCO) cells at 0.1-11.4 μM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry

PDB ID  None

Predicted Structure Download  DRAVPe01554

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Inactivation of viruses infecting ectothermic animals by amphibian and piscine antimicrobial peptides.

Pubmed ID   15193922

Reference   Virology. 2004 Jun 1;323(2):268-75.

Author   Chinchar VG, Bryan L, Silphadaung U, Noga E, Wade D, Rollins-Smith L.

DOI   10.1016/j.virol.2004.02.029