General Information


DRAVP ID  DRAVPe01554

Peptide Name   Dermaseptin-1

Sequence  ALWKTMLKKLGTMALHAGKAALGAAADTISQGTQ

Sequence Length  34

UniProt ID  P24302  P80277 

Source  Phyllomedusa sauvagei (Sauvage's leaf frog)



Activity Information


Target Organism  CCV,FV3

Assay 

Activity 

  • [Ref.15193922]Channel Catfish virus(CCV): inhibition of CCV infection in catfish ovary(CCO) cells(reduce viral infectivity by 50% at 3 μM);
  • Frog Virus 3(FV3): inhibition of FV3 infection in fathead minnow(FHM) cells(reduce viral infectivity by 50% at 12 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.11601906]No cytotoxicity against catfish ovary(CCO) cells at 0.1-11.4 μM.

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01554

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C152H257N43O44S2

Absent amino acids  CEFNPRVY

Common amino acids  A

Mass  3455.09

Pl  10

Basic residues  5

Acidic residues  1

Hydrophobic residues  15

Net charge  4

Boman Index  -555

Hydrophobicity  18.53

Aliphatic Index  92.35

Half Life 

  •     Mammalian:4.4 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  5500

Absorbance 280nm  166.67

Polar residues  9



Literature Information


Literature 1

Title   Inactivation of viruses infecting ectothermic animals by amphibian and piscine antimicrobial peptides.

Pubmed ID   15193922

Reference   Virology. 2004 Jun 1;323(2):268-75.

Author   Chinchar VG, Bryan L, Silphadaung U, Noga E, Wade D, Rollins-Smith L.

DOI   10.1016/j.virol.2004.02.029