General Information
DRAVP ID DRAVPe01555
Peptide Name Dermaseptin-4 (DS IV; Dermaseptin-S4, DS4; Frogs, amphibians, animals)
Sequence ALWMTLLKKVLKAAAKAALNAVLVGANA
Sequence Length 28
UniProt ID P80280
Source Phyllomedusa sauvagei (Sauvage's leaf frog)
Activity Information
Target Organism HSV,HIV
Assay Chemiluminescence Reporter Gene Assay
Activity
Hemolytic Activity
Cytotoxicity
Binding Target viral membrane
Mechanism exerts a selective activity on viral particles and disturbs their organization by breaking the viral membrane, leading to the exposure of HIV-1 core and its dissociation.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01555
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C132H229N35O32S
Absent amino acids CDEFHIPQRSY
Common amino acids A
Mass 2850.55
Pl 10.48
Basic residues 4
Acidic residues 0
Hydrophobic residues 19
Net charge 4
Boman Index 2550
Hydrophobicity 103.21
Aliphatic Index 146.79
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 203.7
Polar residues 4
Literature Information
Literature 1
Title Antibacterial properties of dermaseptin S4 derivatives with in vivo activity.
Pubmed ID 11850249
Reference Antimicrob Agents Chemother. 2002 Mar;46(3):689-694.
Author Navon-Venezia S, Feder R, Gaidukov L, Carmeli Y, Mor A.
DOI 10.1128/AAC.46.3.689-694.2002
Literature 2
Title In vitro antiviral activity of dermaseptin S(4) and derivatives from amphibian skin against herpes simplex virus type 2.
Pubmed ID 23161023
Reference J Med Virol. 2013 Feb;85(2):272-81.
Author Bergaoui I, Zairi A, Tangy F, Aouni M, Selmi B, Hani K.
Literature 3
Title The antimicrobial peptide dermaseptin S4 inhibits HIV-1 infectivity in vitro.
Pubmed ID 15780876
Reference Virology. 2005 Apr 10;334(2):264-75.
Author Lorin C, Saidi H, Belaid A, Zairi A, Baleux F, Hocini H, Bélec L, Hani K, Tangy F.