DRAVP ID  DRAVPe01556

Peptide Name   RTD-1(Rhesus theta-defensin 1)

Sequence  GFCRCLCRRGVCRCICTR

Sequence Length  18

UniProt ID  P82271  P82270  Q9TU01 

Source  Macaca mulatta (Rhesus macaque)

Target Organism  HIV

Assay 

Activity 

• [Ref.15210812]HIV-1 A:inhibition of infection in JC53-BL cells(IC50=3.63 ± 0.85 µg/ml);
• HIV-1 B:inhibition of infection in JC53-BL cells(IC50=0.94 ± 0.59 µg/ml);
• HIV-1 C:inhibition of infection in JC53-BL cells(IC50=3.98 ± 0.70 µg/ml);
• HIV-1 CRF01_AE:inhibition of infection in JC53-BL cells(IC50=2.55 ± 1.92 µg/ml);
• HIV-1 D:inhibition of infection in JC53-BL cells(IC50=0.94 ± 0.42 µg/ml);
• HIV-1 G:inhibition of infection in JC53-BL cells(IC50=1.15 ± 0.59 µg/ml);
• HIV-1 BF:inhibition of infection in JC53-BL cells(IC50=2.38 µg/ml).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  gp120,CD4

Mechanism  The peptide binds to gp120 and CD4, thereby inhibiting HIV entry.

PDB ID  1HVZ 

Predicted Structure Download  DRAVPe01556

Linear/Cyclic  Cyclization (N termini to C termini)

N-terminal Modification  Cyclization (N termini to C termini)

C-terminal Modification  Cyclization (N termini to C termini)

Other Modification  Disulfide bonds between Cys3 and Cys16,Cys5 and Cys14,Cys7 and Cys12.

Stereochemistry  L

Literature 1

Title   Activity of alpha- and theta-defensins against primary isolates of HIV-1. 

Pubmed ID   15210812

Reference   J Immunol. 2004 Jul 1;173(1):515-20.

Author   Wang W, Owen SM, Rudolph DL, Cole AM, Hong T, Waring AJ, Lal RB, Lehrer RI.

DOI   10.4049/jimmunol.173.1.515